A Missing Link? LTP and Learning

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Science  17 Oct 1997:
Vol. 278, Issue 5337, pp. 401-402
DOI: 10.1126/science.278.5337.401

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Even since the phenomenon of long-term potentiation (LTP) was described in 1973, it has been a prime candidate for the underlying cellular basis of memory. But as described by Johnston in his Perspective, the evidence for this connection has been flimsy. Now, in a venerable invertebrate model of learning, the siphon withdrawal reflex of the sea slug Aplysia, Murphy and Glanzman have finally provided a firm demonstration of LTP in a synapse known to control an important behavior.