Report

Interneuron Migration from Basal Forebrain to Neocortex: Dependence on Dlx Genes

Science  17 Oct 1997:
Vol. 278, Issue 5337, pp. 474-476
DOI: 10.1126/science.278.5337.474

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

Although previous analyses indicate that neocortical neurons originate from the cortical proliferative zone, evidence suggests that a subpopulation of neocortical interneurons originates within the subcortical telencephalon. For example, γ-aminobutyric acid (GABA)–expressing cells migrate in vitro from the subcortical telencephalon into the neocortex. The number of GABA-expressing cells in neocortical slices is reduced by separating the neocortex from the subcortical telencephalon. Finally, mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few GABA-expressing cells in the neocortex.

  • * To whom correspondence should be addressed. E-mail: jlrr{at}cgl.ucsf.edu

View Full Text

Related Content