Delivering Copper Inside Yeast and Human Cells

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Science  31 Oct 1997:
Vol. 278, Issue 5339, pp. 817-818
DOI: 10.1126/science.278.5339.817

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In their Perspective, Valentine and Gralla summarize the emerging picture of a series of transport proteins that shuttle the toxic metal, copper, safely around the cell, delivering it to nascent enzymes that rely on copper for proper catalytic function. A report in this week's issue by Pufahl et al. describes the delivery of copper to Fet3 by Atx1.