Report

Vigorous HIV-1-Specific CD4+ T Cell Responses Associated with Control of Viremia

Science  21 Nov 1997:
Vol. 278, Issue 5342, pp. 1447-1450
DOI: 10.1126/science.278.5342.1447

You are currently viewing the abstract.

View Full Text
As a service to the community, AAAS/Science has made this article free with registration.

Abstract

Virus-specific CD4+ T helper lymphocytes are critical to the maintenance of effective immunity in a number of chronic viral infections, but are characteristically undetectable in chronic human immunodeficiency virus–type 1 (HIV-1) infection. In individuals who control viremia in the absence of antiviral therapy, polyclonal, persistent, and vigorous HIV-1–specific CD4+ T cell proliferative responses were present, resulting in the elaboration of interferon-γ and antiviral β chemokines. In persons with chronic infection, HIV-1–specific proliferative responses to p24 were inversely related to viral load. Strong HIV-1–specific proliferative responses were also detected following treatment of acutely infected persons with potent antiviral therapy. The HIV-1–specific helper cells are likely to be important in immunotherapeutic interventions and vaccine development.

  • * To whom correspondence should be addressed. E-mail: bwalker{at}helix.mgh.harvard.edu

View Full Text

Cited By...