Special News ReportImmunology

Ways to Vary the Gene Vaccine Theme

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Science  05 Dec 1997:
Vol. 278, Issue 5344, pp. 1713
DOI: 10.1126/science.278.5344.1713

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When researchers first reported in Science more than 7 years ago that directly injecting DNA into a muscle could lead to the production of proteins (see main text), they concluded that the finding "may provide alternative approaches to vaccine development." That's turned out to be a classic scientific understatement: So many researchers are now developing so-called DNA vaccines that entire scientific meetings are devoted to the topic, it has its own Internet site, and biotech companies are tripping over each other to get into the business. And, as is true in any booming scientific field, researchers have come up with many creative variations on the original theme.