PerspectiveTRANSCRIPTION

Getting Around the Nucleosomes

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Science  12 Dec 1997:
Vol. 278, Issue 5345, pp. 1899-1901
DOI: 10.1126/science.278.5345.1899

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Summary

Inside cells, DNA, the genetic material, is wound around tiny spools of protein called nucleosomes. This efficient packaging method can makes DNA inaccessible for enzymes that make new DNA or proteins that regulate genes. In his Perspective, Widom explains how the cell solves this problem and what we learn from new experiments, presented in this issue by Studitsky et al., that illuminate the workings of one very big eukaryotic polymerase, polymerase III.