Arabidopsis NPH1: A Protein Kinase with a Putative Redox-Sensing Domain

Science  19 Dec 1997:
Vol. 278, Issue 5346, pp. 2120-2123
DOI: 10.1126/science.278.5346.2120

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The NPH1 (nonphototropic hypocotyl 1) gene encodes an essential component acting very early in the signal-transduction chain for phototropism. Arabidopsis NPH1 contains a serine-threonine kinase domain and LOV1 and LOV2 repeats that share similarity (36 to 56 percent) with Halobacterium salinariumBat, Azotobacter vinelandii NIFL, Neurospora crassa White Collar–1, Escherichia coli Aer, and the Eag family of potassium-channel proteins from Drosophila and mammals. Sequence similarity with a known (NIFL) and a suspected (Aer) flavoprotein suggests that NPH1 LOV1 and LOV2 may be flavin-binding domains that regulate kinase activity in response to blue light–induced redox changes.

  • * Present address: DNA Plant Technology, 6701 San Pablo Avenue, Oakland, CA 94508, USA.

  • Present address: Biology Department, University of Missouri, Columbia, MO 65211, USA.

  • Present address: Department of Biology, University of Ulsan, Kyungnam, Ulsan 680-749, Korea.

  • § Present address: Department of Botany and Plant Science, University of California, Riverside, CA 92521, USA.

  • || To whom correspondence should be addressed. E-mail: briggs{at}

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