Report

Requirement for DCP-1 Caspase During Drosophila Oogenesis

See allHide authors and affiliations

Science  09 Jan 1998:
Vol. 279, Issue 5348, pp. 230-234
DOI: 10.1126/science.279.5348.230

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

This article has a correction. Please see:

Abstract

Caspases, a class of cysteine proteases, are an essential component of the apoptotic cell death program. DuringDrosophila oogenesis, nurse cells transfer their cytoplasmic contents to developing oocytes and then die. Loss of function for thedcp-1 gene, which encodes a caspase, caused female sterility by inhibiting this transfer. dcp-1 nurse cells were defective in the cytoskeletal reorganization and nuclear breakdown that normally accompany this process. Thedcp-1 phenotype suggests that the cytoskeletal and nuclear events in the nurse cells make use of the machinery normally associated with apoptosis and that apoptosis of the nurse cells is a necessary event for oocyte development.

View Full Text