Functional Expression of a Mammalian Odorant Receptor

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Science  09 Jan 1998:
Vol. 279, Issue 5348, pp. 237-242
DOI: 10.1126/science.279.5348.237

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Candidate mammalian odorant receptors were first cloned some 6 years ago. The physiological function of these receptors in initiating transduction in olfactory receptor neurons remains to be established. Here, a recombinant adenovirus was used to drive expression of a particular receptor gene in an increased number of sensory neurons in the rat olfactory epithelium. Electrophysiological recording showed that increased expression of a single gene led to greater sensitivity to a small subset of odorants.

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