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Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

Science  23 Jan 1998:
Vol. 279, Issue 5350, pp. 563-566
DOI: 10.1126/science.279.5350.563

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Abstract

Insulin-like growth factor–I (IGF-I) is a mitogen for prostate epithelial cells. To investigate associations between plasma IGF levels and prostate cancer risk, a nested case-control study within the Physicians' Health Study was conducted on prospectively collected plasma from 152 cases and 152 controls. A strong positive association was observed between IGF-I levels and prostate cancer risk. Men in the highest quartile of IGF-I levels had a relative risk of 4.3 (95 percent confidence interval 1.8 to 10.6) compared with men in the lowest quartile. This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment.

  • * To whom correspondence should be addressed. E-mail: jmlchan{at}hsph.harvard.edu

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