After Dolly, a Pharming Frenzy

Science  30 Jan 1998:
Vol. 279, Issue 5351, pp. 646-648
DOI: 10.1126/science.279.5351.646

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BOSTON-- New successes in using DNA from fetal cells to clone transgenic animals have galvanized efforts to create transgenic livestock that will act as living factories, producing pharmaceutical products in their milk for treating human diseases and, perhaps, organs for transplantation. In the year since the announcement of Dolly's birth, a dozen other groups have been adapting the technique used by the team in Scotland. But a crucial difference between these experiments and the original Dolly breakthrough remains: Dolly was cloned from adult cells, but the later experiments all use nuclei from fetal cells. Indeed, so far the Dolly experiment has not been exactly replicated, and some scientists have even questioned whether Dolly is in fact the clone of an adult (see sidebar, letter on p. 635).