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Transcription Factor-Specific Requirements for Coactivators and Their Acetyltransferase Functions

Science  30 Jan 1998:
Vol. 279, Issue 5351, pp. 703-707
DOI: 10.1126/science.279.5351.703

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Abstract

Different classes of mammalian transcription factors—nuclear receptors, cyclic adenosine 3′,5′-monophosphate–regulated enhancer binding protein (CREB), and signal transducer and activator of transcription-1 (STAT-1)—functionally require distinct components of the coactivator complex, including CREB-binding protein (CBP/p300), nuclear receptor coactivators (NCoAs), and p300/CBP-associated factor (p/CAF), based on their platform or assembly properties. Retinoic acid receptor, CREB, and STAT-1 also require different histone acetyltransferase (HAT) activities to activate transcription. Thus, transcription factor–specific differences in configuration and content of the coactivator complex dictate requirements for specific acetyltransferase activities, providing an explanation, at least in part, for the presence of multiple HAT components of the complex.

  • * To whom correspondence should be addressed. E-mail: mrosenfeld{at}ucsd.edu

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