Putting the pieces back together

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Science  06 Feb 1998:
Vol. 279, Issue 5352, pp. 777k
DOI: 10.1126/science.279.5352.777k

Processing of pre-messenger RNA (mRNA) involves multiple RNA and protein interactions in the form of small nuclear ribonucleoprotein particles (snRNPs). In the spliceosomal machinery, the association of U4 and U6 snRNPs through extensive base pairing is disrupted for activation of the spliceosome and catalysis of splicing. For subsequent rounds of splicing, U4 and U6 snRNPs must reanneal to form duplex U4/U6 snRNP. Raghunathan and Guthrie (p. 857) identify a specific RNA annealing protein, Prp24, that functions in a U4/U6 snRNP recycling pathway for multiple rounds of pre-mRNA splicing.

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