Impaired Locomotion and Dopamine Signaling in Retinoid Receptor Mutant Mice

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Science  06 Feb 1998:
Vol. 279, Issue 5352, pp. 863-867
DOI: 10.1126/science.279.5352.863

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In the adult mouse, single and compound null mutations in the genes for retinoic acid receptor β and retinoid X receptors β and γ resulted in locomotor defects related to dysfunction of the mesolimbic dopamine signaling pathway. Expression of the D1 and D2 receptors for dopamine was reduced in the ventral striatum of mutant mice, and the response of double null mutant mice to cocaine, which affects dopamine signaling in the mesolimbic system, was blunted. Thus, retinoid receptors are involved in the regulation of brain functions, and retinoic acid signaling defects may contribute to pathologies such as Parkinson's disease and schizophrenia.

  • * These authors contributed equally to this work.

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