Autophosphorylation at Thr286 of the α Calcium-Calmodulin Kinase II in LTP and Learning

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Science  06 Feb 1998:
Vol. 279, Issue 5352, pp. 870-873
DOI: 10.1126/science.279.5352.870

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The calcium-calmodulin–dependent kinase II (CaMKII) is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)–dependent activity, CaMKII can undergo autophosphorylation, resulting in CaM-independent activity. A point mutation was introduced into the αCaMKII gene that blocked the autophosphorylation of threonine at position 286 (Thr286) of this kinase without affecting its CaM-dependent activity. The mutant mice had noN-methyl-d-aspartate receptor–dependent LTP in the hippocampal CA1 area and showed no spatial learning in the Morris water maze. Thus, the autophosphorylation of αCaMKII at Thr286 appears to be required for LTP and learning.

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