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The Structure of GABPα/β: An ETS Domain- Ankyrin Repeat Heterodimer Bound to DNA

Science  13 Feb 1998:
Vol. 279, Issue 5353, pp. 1037-1041
DOI: 10.1126/science.279.5353.1037

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Abstract

GA-binding protein (GABP) is a transcriptional regulator composed of two structurally dissimilar subunits. The α subunit contains a DNA-binding domain that is a member of the ETS family, whereas the β subunit contains a series of ankyrin repeats. The crystal structure of a ternary complex containing a GABPα/β ETS domain–ankyrin repeat heterodimer bound to DNA was determined at 2.15 angstrom resolution. The structure shows how an ETS domain protein can recruit a partner protein using both the ETS domain and a carboxyl-terminal extension and provides a view of an extensive protein-protein interface formed by a set of ankyrin repeats. The structure also reveals how the GABPα ETS domain binds to its core GGA DNA-recognition motif.

  • * To whom correspondence should be addressed. E-mail: cynthia{at}groucho.med.jhmi.edu

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