Report

The Minor Histocompatibility Antigen HA-1: A Diallelic Gene with a Single Amino Acid Polymorphism

Science  13 Feb 1998:
Vol. 279, Issue 5353, pp. 1054-1057
DOI: 10.1126/science.279.5353.1054

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Abstract

The minor histocompatibility antigen (mHag) HA-1 is the only known mHag for which mismatching is correlated with the development of severe graft versus host disease (GvHD) after human leukocyte antigen–identical bone marrow transplantation. HA-1 was found to be a nonapeptide derived from an allele of the KIAA0223gene. The HA-1–negative allelic counterpart encoded byKIAA0223 had one amino acid difference from HA-1. Family analysis with HA-1 allele-specific polymerase chain reaction showed an exact correlation between this allelic polymorphism and the HA-1 phenotype. HA-1 allele typing of donor and recipient should improve donor selection and allow the determination of bone marrow transplantation recipients with high risk for HA-1–induced GvHD development.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: ihbsecr{at}euronet.nl

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