News & CommentX-ray Crystallography

Taking a Structured Approach to Understanding Proteins

See allHide authors and affiliations

Science  13 Feb 1998:
Vol. 279, Issue 5353, pp. 978-979
DOI: 10.1126/science.279.5353.978

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Knowing the structures of all the proteins encoded by the flood of gene sequences pouring into the public databases would give a big boost to biomedical researchers seeking to understand those genes' functions, but even if it were possible to determine all of them, it would take a tremendous amount of time and resources. Meeting 24 and 25 January at Argonne National Laboratory outside Chicago, a group of researchers agreed that the goal should be to determine the structures of a set of molecules representing all types of protein structure. They say this would yield almost as good a picture of the universe of proteins as attempting to get the three-dimensional structure of every one that turns up through gene sequencing, which in the case of the human genome could be 100,000.