Research CommentariesCELL CYCLE

Mitotic Arrest: Mad2 Prevents Sleepy from Waking Up the APC

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Science  13 Feb 1998:
Vol. 279, Issue 5353, pp. 999-1000
DOI: 10.1126/science.279.5353.999

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The cell cycle is a precisely orchestrated series of biochemical events that results in replication of the contents of a cell and delivery of the new components to two daughter cells. Ensuring that all the pieces are in place are a series of checkpoints that stop the action if all is not well. In his research commentary, Elledge discusses recent progress in understanding the checkpoint that prevents the duplicated chromosomes from being separated into the daughter cells unless one sister is attached to the pulling apparatus from each daughter-cell-to-be. Results in two reports in this issue ( Kim et al . and Hwang et al .) identify the molecular players in this checkpoint machinery.