Report

Rapid Turnover of T Lymphocytes in SIV-Infected Rhesus Macaques

See allHide authors and affiliations

Science  20 Feb 1998:
Vol. 279, Issue 5354, pp. 1223-1227
DOI: 10.1126/science.279.5354.1223

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

Studies of lymphocyte turnover in animal models have implications for understanding the mechanism of cell killing and the extent of lymphocyte regeneration in human immunodeficiency virus infection. Quantitative analyses of the sequential changes in bromodeoxyuridine labeling of CD4 and CD8 T lymphocytes not only revealed the normal proliferation and death rates of these cell populations in uninfected macaques, but also showed a substantial increase in these rates associated with simian immunodeficiency virus (SIV) infection. Faster labeling and delabeling in memory and naı̈ve T lymphocyte subpopulations as well as in NK (natural killer) and B cells were also observed in infected macaques, suggesting a state of generalized activation induced by SIV.

  • * To whom correspondence should be addressed. E-mail: dho{at}adarc.org

View Full Text