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Propagating Activity Patterns in Large-Scale Inhibitory Neuronal Networks

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Science  27 Feb 1998:
Vol. 279, Issue 5355, pp. 1351-1355
DOI: 10.1126/science.279.5355.1351

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Abstract

The propagation of activity is studied in a spatially structured network model of γ-aminobutyric acid–containing (GABAergic) neurons exhibiting postinhibitory rebound. In contrast to excitatory-coupled networks, recruitment spreads very slowly because cells fire only after the postsynaptic conductance decays, and with two possible propagation modes. If the connection strength decreases monotonically with distance (on-center), then propagation occurs in a discontinuous manner. If the self- and nearby connections are absent (off-center), propagation can proceed smoothly. Modest changes in the synaptic reversal potential can result in depolarization-mediated waves that are 25 times faster. Functional and developmental roles for these behaviors and implications for thalamic circuitry are suggested.

  • * Present address: Center for Neural Science and Courant Institute of Mathematical Sciences, New York University, New York, NY 10003, USA. To whom correspondence should be addressed at the Center for Neural Science, 4 Washington Place, Room 809, New York University, New York, NY 10003, USA. E-mail: rinzel{at}cns.nyu.edu

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