Report

Src Activation in the Induction of Long-Term Potentiation in CA1 Hippocampal Neurons

See allHide authors and affiliations

Science  27 Feb 1998:
Vol. 279, Issue 5355, pp. 1363-1368
DOI: 10.1126/science.279.5355.1363

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

Long-term potentiation (LTP) is an activity-dependent strengthening of synaptic efficacy that is considered to be a model of learning and memory. Protein tyrosine phosphorylation is necessary to induce LTP. Here, induction of LTP in CA1 pyramidal cells of rats was prevented by blocking the tyrosine kinase Src, and Src activity was increased by stimulation producing LTP. Directly activating Src in the postsynaptic neuron enhanced excitatory synaptic responses, occluding LTP. Src-induced enhancement of α-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) receptor–mediated synaptic responses required raised intracellular Ca2+ and N-methyl-d-aspartate (NMDA) receptors. Thus, Src activation is necessary and sufficient for inducing LTP and may function by up-regulating NMDA receptors.

  • * To whom correspondence should be addressed. E-mail: roder{at}mshri.on.ca

View Full Text