Report

Natural Ligand of Mouse CD1d1: Cellular Glycosylphosphatidylinositol

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Science  06 Mar 1998:
Vol. 279, Issue 5356, pp. 1541-1544
DOI: 10.1126/science.279.5356.1541

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Abstract

Mouse CD1d1, a member of the CD1 family of evolutionarily conserved major histocompatibility antigen–like molecules, controls the differentiation and function of a T lymphocyte subset, NK1+natural T cells, proposed to regulate immune responses. The CD1d1 crystal structure revealed a large hydrophobic binding site occupied by a ligand of unknown chemical nature. Mass spectrometry and metabolic radiolabeling were used to identify cellular glycosylphosphatidylinositol as a major natural ligand of CD1d1. CD1d1 bound glycosylphosphatidylinositol through its phosphatidylinositol aspect with high affinity. Glycosylphosphatidylinositol or another glycolipid could be a candidate natural ligand for CD1d1-restricted T cells.

  • * To whom correspondence should be addressed. E-mail: sjoyce{at}bcmic.hmc.psu.edu

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