The Bare Bones of Catalysis

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Science  20 Mar 1998:
Vol. 279, Issue 5358, pp. 1852
DOI: 10.1126/science.279.5358.1852

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Biochemists using an artificial form of evolution have created a redesigned enzyme that still performs the function of its natural counterpart. By tearing apart an enzyme and pushing its fragments through a round of mutation and selection to recover the original function, researchers report on page 1958 that they have come up with a new, smaller version that is equally adept at the original job.