Research CommentariesHuman Genetics

Progress in Progressive Hearing Loss

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Science  20 Mar 1998:
Vol. 279, Issue 5358, pp. 1870-1871
DOI: 10.1126/science.279.5358.1870

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Defects in different genes underlie the many kinds of genetic deafness. In this issue, Vahava et al. report that a mutation in the transcription factor POU4F3 is the cause of deafness in a large Israeli family. In her commentary, Steel discusses how the malfunctioning of this transcription factor may lead to progressive deafness, with onset at age 18.