Research CommentariesTRANSCRIPTION

Promoter Logic

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Science  20 Mar 1998:
Vol. 279, Issue 5358, pp. 1871-1872
DOI: 10.1126/science.279.5358.1871

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Promoters, sequences of DNA upstream of the coding region of a gene, confer regulation to the gene, responding to signals to turn up, down, on, or off the gene's transcription. In a research article in this issue, Yuh et al . have so methodically quantitated the function of each module within a sea urchin promoter that they are able to build a computer model of the apparatus. In his commentary, Wray describes the unique features of this well-described promoter and the general principles that it teaches us about the evolution of gene regulation.