Dependence of BSAP Repressor and Activator Functions on BSAP Concentration

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Science  20 Mar 1998:
Vol. 279, Issue 5358, pp. 1961-1964
DOI: 10.1126/science.279.5358.1961

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During a B cell immune response, the transcription factor BSAP maintains its activator functions but is relieved of its repressor functions. This selective targeting of BSAP activities was shown to be regulated by a concentration-dependent mechanism whereby activator motifs for BSAP had a 20-fold higher binding affinity than repressor motifs. An exchange of activator and repressor motifs, however, showed that the context of the motif, rather than the affinity, determined whether BSAP operated as an activator or repressor.

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