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Monoallelic Expression of the Interleukin-2 Locus

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Science  27 Mar 1998:
Vol. 279, Issue 5359, pp. 2118-2121
DOI: 10.1126/science.279.5359.2118

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Abstract

The lymphokine interleukin-2 (IL-2) is responsible for autocrine cell cycle progression and regulation of immune responses. Uncontrolled secretion of IL-2 results in adverse reactions ranging from anergy, to aberrant T cell activation, to autoimmunity. With the use of fluorescent in situ hybridization and single-cell polymerase chain reaction in cells with different IL-2 alleles, IL-2 expression in mature thymocytes and T cells was found to be tightly controlled by monoallelic expression. Because IL-2 is encoded at a nonimprinted autosomal locus, this result represents an unusual regulatory mode for controlling the precise expression of a single gene.

  • Both authors contributed equally to this work.

  • Present address: Education and Research Center, St. Vincent Hospital, Elm Park, Dublin, Ireland.

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