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Generation of Intestinal T Cells from Progenitors Residing in Gut Cryptopatches

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Science  10 Apr 1998:
Vol. 280, Issue 5361, pp. 275-278
DOI: 10.1126/science.280.5361.275

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Abstract

Cryptopatches (CPs) are part of the murine intestinal immune compartment. Cells isolated from CPs of the small intestine that were c-kit positive (c-kit+) but lineage markers negative (Lin) gave rise to T cell receptor (TCR) αβ and TCR γδ intestinal intraepithelial T cells after in vivo transfer or tissue engraftment into severe combined immunodeficient mice. In contrast, cells from Peyer's patches and mesenteric lymph nodes, which belong in the same intestinal immune compartment but lack c-kit+Lin cells, failed to do so. These findings and results of electron microscopic analysis provide evidence of a local intestinal T cell precursor that develops in the CPs.

  • * To whom correspondence should be addressed. E-mail: ishikawa{at}sun.microb.med.keio.ac.jp

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