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A Marine Natural Product Inhibitor of Kinesin Motors

Science  10 Apr 1998:
Vol. 280, Issue 5361, pp. 292-295
DOI: 10.1126/science.280.5361.292

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Abstract

Members of the kinesin superfamily of motor proteins are essential for mitotic and meiotic spindle organization, chromosome segregation, organelle and vesicle transport, and many other processes that require microtubule-based transport. A compound, adociasulfate-2, was isolated from a marine sponge, Haliclona (also known asAdocia) species, that inhibited kinesin activity by targeting its motor domain and mimicking the activity of the microtubule. Thus, the kinesin-microtubule interaction site could be a useful target for small molecule modulators, and adociasulfate-2 should serve as an archetype for specific inhibitors of kinesin functions.

  • * To whom correspondence should be addressed. E-mail: lgoldstein{at}ucsd.edu

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