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Dependence of Germinal Center B Cells on Expression of CD21/CD35 for Survival

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Science  24 Apr 1998:
Vol. 280, Issue 5363, pp. 582-585
DOI: 10.1126/science.280.5363.582

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Abstract

Affinity-driven selection of B lymphocytes within germinal centers is critical for the development of high-affinity memory cells and host protection. To investigate the role of the CD21/CD35 coreceptor in B cell competition for follicular retention and survival within the germinal center, either Cr2+ or Cr2nulllysozyme-specific transgenic B cells were adoptively transferred into normal mice immunized with duck (DEL) or turkey (TEL) lysozyme, which bind with different affinities. In mice injected with high-affinity turkey lysozyme, Cr2null B cells responded by follicular retention; however, they could not survive within germinal centers. This suggests that CD21 provides a signal independent of antigen that is required for survival of B cells in the germinal center.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: mcarroll{at}warren.med.harvard.edu

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