Report

Genetic Evaluation of Suspected Cases of Transient HIV-1 Infection of Infants

See allHide authors and affiliations

Science  15 May 1998:
Vol. 280, Issue 5366, pp. 1073-1077
DOI: 10.1126/science.280.5366.1073

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

Detection of human immunodeficiency virus–type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.

  • * To whom correspondence should be addressed at the Department of Pediatrics, Division of Infectious Diseases, University of Washington, 4800 Sand Point Way N.E., Box 329500, Seattle, WA 98105, USA. E-mail: lfrenkel{at}u.washington.edu

View Full Text