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Genetic Evaluation of Suspected Cases of Transient HIV-1 Infection of Infants

Science  15 May 1998:
Vol. 280, Issue 5366, pp. 1073-1077
DOI: 10.1126/science.280.5366.1073

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Abstract

Detection of human immunodeficiency virus–type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.

  • * To whom correspondence should be addressed at the Department of Pediatrics, Division of Infectious Diseases, University of Washington, 4800 Sand Point Way N.E., Box 329500, Seattle, WA 98105, USA. E-mail: lfrenkel{at}u.washington.edu

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