Improving the wonder drug?

See allHide authors and affiliations

Science  22 May 1998:
Vol. 280, Issue 5367, pp. 1165
DOI: 10.1126/science.280.5367.1165j

Aspirin, one of the most widely used drugs in the world, works by acetylating and irreversibly inactivating the cyclooxygenase (COX) enzymes. Aspirin's therapeutic effects, such as acting as an anti-inflammatory, are mediated by its action on COX-2, and its adverse effects, such as ulcers, are mediated by its action on COX-1. Kalgutkar et al. (p. 1268, see the news story by Pennisi, p. 1191) have designed aspirin-like compounds that preferentially acetylate and inactivate COX-2 both in vitro and in cell culture assays. This design strategy may lead to the development of aspirin-like drugs that are free of side effects.

Navigate This Article