Research NewsBiomedicine

Building a Better Aspirin

See allHide authors and affiliations

Science  22 May 1998:
Vol. 280, Issue 5367, pp. 1191-1192
DOI: 10.1126/science.280.5367.1191

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Summary

The beneficial effects of aspirin and its cousins, such as ibuprofen and acetaminophen, come from their ability to block an enzyme, called cyclooxygenase-2 (COX-2), that promotes inflammation, pain, and fevers. Unfortunately, the drugs are even more effective at inhibiting COX-1, a related enzyme essential for the health of the stomach and kidneys. Now two compounds that selectively inhibit COX-2 may be in drugstores within the next year, and a new wave of COX-2 inhibitors that could eventually be even more potent is also taking shape (see Report on p. 1268).