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Requirement for γδ T Cells in Allergic Airway Inflammation

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Science  22 May 1998:
Vol. 280, Issue 5367, pp. 1265-1267
DOI: 10.1126/science.280.5367.1265

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Abstract

The factors that contribute to allergic asthma are unclear but the resulting condition is considered a consequence of a type-2 T helper (TH2) cell response. In a model of pulmonary allergic inflammation, mice that lacked γδ T cells had decreases in specific immunoglobulin E (IgE) and IgG1 and pulmonary interleukin-5 (IL-5) release as well as in eosinophil and T cell infiltration compared with wild-type mice. These responses were restored by administration of IL-4 to γδ T cell-deficient mice during the primary immunization. Thus, γδ T cells are essential for inducing IL-4-dependent IgE and IgG1 responses and for TH2-mediated airway inflammation to peptidic antigens.

  • * Present address: Novartis Horsham Research Centre, Horsham, UK.

  • These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: mpretol{at}pasteur.fr

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