Growing Joints Use Their Noggins

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Science  29 May 1998:
Vol. 280, Issue 5368, pp. 1350
DOI: 10.1126/science.280.5368.1350a

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Steven Dickman In new research presented on page 1455 of this issue, molecular embryologists have found that mice lacking noggin, a gene first discovered as important in brain and nerve development, have no joints at all but instead have stubby, continuous limbs, along with a fatal array of other developmental defects. The finding is a step toward a more detailed understanding of embryonic development and offers potential medical benefits in diseases where there is too much bone or even too little.