Research CommentariesNeuroscience

Glutamate Receptor Activation: A Four-Step Program

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Science  05 Jun 1998:
Vol. 280, Issue 5369, pp. 1547-1548
DOI: 10.1126/science.280.5369.1547

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Receptors for neurotransmitters are often also ion channels, made up of more than one subunit working together as a unit. In this issue, Rosenmund et al . present a kinetic analysis of an ionotropic glutamate receptor that indicates that it is a tetramer, not a pentamer as thought before. In his commentary, Miller explains the elegant experiment that leads to this surprising conclusion.