Sifting Through and Making Sense of Genome Sequences

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Science  12 Jun 1998:
Vol. 280, Issue 5370, pp. 1692-1693
DOI: 10.1126/science.280.5370.1692

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COLD SPRING HARBOR, NEW YORK-- The genomics community's annual meeting on Genome Mapping, Sequencing, and Biology once focused mostly on developing better mapping and sequencing technologies. But at this year's meeting, held here from 13 to 17 May, participants were more caught up in trying to make sense of the sequence data being produced. For instance, geneticists are using new computer algorithms to identify genes encoding RNAs, which are more difficult to find than protein-coding genes. They've also found new ways to identify single-base changes in genes that can be used to nail down the genes that contribute to the development of multigene diseases, and are solving difficult problems in evolutionary biology by comparing the patterns of gene duplications in different species.