Research CommentariesPROTEIN STRUCTURE

Cytochrome c Oxidase: One Enzyme, Two Mechanisms?

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Science  12 Jun 1998:
Vol. 280, Issue 5370, pp. 1712-1713
DOI: 10.1126/science.280.5370.1712

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A research article in this week's issue by Yoshikawa et al . reports the structure of cytochrome c oxidase, an enzyme critical for a large fraction of aerobic respiration. In his commentary, Gennis explains how this structure relates to two previously published structures of the same enzyme and analyzes the controversial proton-pumping mechanism that the authors propose on the basis of their structure.