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Ken Garber The Feline Genome Project at the National Cancer Institute (NCI) expects to achieve a major milestone this year: a complete map of the cat genome. Because cats and humans share almost 60 inherited diseases, including polycystic kidney disease, diabetes, heart muscle disorders, and certain common immune cell cancers, the map could be a useful guide to human disease genes. Once the cat map is in hand, the NCI group plans to use it to track down the cat disease genes and then mine the comparable regions of the human and mouse genomes for candidates for their human counterparts. If the same genes turn out to be at fault in both species, then cats would also provide good models for the human diseases.