Special Articles

The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens

Science  19 Jun 1998:
Vol. 280, Issue 5371, pp. 1884-1888
DOI: 10.1126/science.280.5371.1884

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

The human immunodeficiency virus–type 1 (HIV-1) envelope glycoproteins interact with receptors on the target cell and mediate virus entry by fusing the viral and cell membranes. The structure of the envelope glycoproteins has evolved to fulfill these functions while evading the neutralizing antibody response. An understanding of the viral strategies for immune evasion should guide attempts to improve the immunogenicity of the HIV-1 envelope glycoproteins and, ultimately, aid in HIV-1 vaccine development.

  • * To whom correspondence should be addressed. E-mail: joseph_sodroski{at}dfci.harvard.edu

View Full Text

Related Content