Research CommentariesSignal Transduction

G Proteins and Small GTPases: Distant Relatives Keep in Touch

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Science  26 Jun 1998:
Vol. 280, Issue 5372, pp. 2074-2075
DOI: 10.1126/science.280.5372.2074

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Both low molecular weight G proteins and the larger heterotrimeric G proteins are switched on and off by binding the nucleotide GTP. New results in this issue by Kosaza et al . and Hart et al . show that these two distant relatives actually regulate one another. Hall explains in his commentary that this advance is more than just a family reunion and actually reveals the mechanism by which many fundamental cell processes that alter cell shape are regulated, including gastrulation.