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Drosophila Synapse Formation: Regulation by Transmembrane Protein with Leu-Rich Repeats, CAPRICIOUS

Science  26 Jun 1998:
Vol. 280, Issue 5372, pp. 2118-2121
DOI: 10.1126/science.280.5372.2118

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Abstract

Upon reaching the target region, neuronal growth cones transiently search through potential targets and form synaptic connections with only a subset of these. The capricious (caps) gene may regulate these processes in Drosophila. capsencodes a transmembrane protein with leucine-rich repeats (LRRs). During the formation of neuromuscular synapses, caps is expressed in a small number of synaptic partners, including muscle 12 and the motorneurons that innervate it. Loss-of-function and ectopic expression of caps alter the target specificity of muscle 12 motorneurons, indicating a role for caps in selective synapse formation.

  • * To whom correspondence should be addressed. E-mail: nose{at}bio.phys.s.u-tokyo.ac.jp

  • Present address: Department of Physics, School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113–8654, Japan.

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