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Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node

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Science  03 Jul 1998:
Vol. 281, Issue 5373, pp. 96-99
DOI: 10.1126/science.281.5373.96

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Abstract

Early events in the humoral immune response were visualized in lymph nodes by simultaneous tracking of antigen-specific CD4 T and B cells after immunization. The T cells were initially activated in the T cell areas when the B cells were still randomly dispersed in the B cell–rich follicles. Both populations then migrated to the edges of the follicles and interacted there, resulting in CD154-dependent B cell proliferation and germinal center formation. These results provide visual documentation of cognate T-B cell interactions and localize them to the follicular border.

  • * These authors contributed equally to this work.

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