PerspectiveCELL CYCLE

Rad9 Comes of Age

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Science  10 Jul 1998:
Vol. 281, Issue 5374, pp. 185-186
DOI: 10.1126/science.281.5374.185

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Summary

When their genetic material is damaged, cells prudently refrain from starting cell division (or mitosis). A prominent component of the cellular machinery that puts this brake on the cell, the protein Rad9, has now been identified by Sun et al . Walworth explains in her Perspective how this work now suggests a mechanism by which Rad9 and another protein Rad53 stop the cell cycle.