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Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development

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Science  17 Jul 1998:
Vol. 281, Issue 5375, pp. 416-419
DOI: 10.1126/science.281.5375.416

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Abstract

The leukocyte-specific adapter molecule SLP-76 (Src homology 2 domain–containing leukocyte protein of 76 kilodaltons) is rapidly phosphorylated on tyrosine residues after receptor ligation in several hematopoietically derived cell types. Mice made deficient for SLP-76 expression contained no peripheral T cells as a result of an early block in thymopoiesis. Macrophage and natural killer cell compartments were intact in SLP-76–deficient mice, despite SLP-76 expression in these lineages in wild-type mice. Thus, the SLP-76 adapter protein is required for normal thymocyte development and plays a crucial role in translating signals mediated by pre–T cell receptors into distal biochemical events.

  • * To whom correspondence should be addressed. E-mail: gary-koretzky{at}uiowa.edu

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