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Science  24 Jul 1998:
Vol. 281, Issue 5376, pp. 483
DOI: 10.1126/science.281.5376.483e

One puzzle of immunology is that T cell surface receptors don't simply switch on and off; instead, they respond in a range of ways, depending on how tightly a ligand binds to them. In the Perspective on p. 528, Malissen discusses two reports that help explain why. The online article offers Web links to tutorials on the immune system, antibody databases, and many other resources.

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