PerspectiveImmunology

Translating Affinity into Response

See allHide authors and affiliations

Science  24 Jul 1998:
Vol. 281, Issue 5376, pp. 528-529
DOI: 10.1126/science.281.5376.528

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Summary

At first glance, signaling molecules that interact with cell-surface receptors would seem to have only two choices--to bind to the receptor to turn it on or dissociate to turn it off. But then how can one explain the diverse responses elicited by molecules that interact with the same receptor? In his Perspective, Malissen discusses new findings, including two reports in this week's issue by Torigoe and Neumeister Kersch, that suggest a molecular solution to this mystery.