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A Viral Mechanism for Inhibition of the Cellular Phosphatase Calcineurin

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Science  24 Jul 1998:
Vol. 281, Issue 5376, pp. 562-565
DOI: 10.1126/science.281.5376.562

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Abstract

The transcription factor NFAT (nuclear factor of activated T cells) controls the expression of many immunomodulatory proteins. African swine fever virus inhibits proinflammatory cytokine expression in infected macrophages, and a viral protein A238L was found to display the activity of the immunosuppressive drug cyclosporin A by inhibiting NFAT-regulated gene transcription in vivo. This it does by binding the catalytic subunit of calcineurin and inhibiting calcineurin phosphatase activity.

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