Report

A Viral Mechanism for Inhibition of the Cellular Phosphatase Calcineurin

See allHide authors and affiliations

Science  24 Jul 1998:
Vol. 281, Issue 5376, pp. 562-565
DOI: 10.1126/science.281.5376.562

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

The transcription factor NFAT (nuclear factor of activated T cells) controls the expression of many immunomodulatory proteins. African swine fever virus inhibits proinflammatory cytokine expression in infected macrophages, and a viral protein A238L was found to display the activity of the immunosuppressive drug cyclosporin A by inhibiting NFAT-regulated gene transcription in vivo. This it does by binding the catalytic subunit of calcineurin and inhibiting calcineurin phosphatase activity.

View Full Text